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https://doi.org/10.1016/j.stem.2024.03.009
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Cite Journal: Cell Stem Cell |  Publication Date: Apr 1, 2024 |
The chemokine receptors CCR5 and CXCR4 are "front doors" for HIV-1 infection in host cells, and their targeting represents a potential solution for a cure. Dudek etal.1 now propose a new gene editing strategy to simultaneously block CCR5- and CXCR4-mediated HIV-1 entry in autologous hematopoietic stem and progenitor cells (HSPCs).
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