Abstract

The basic multiple regression model for the analysis of selected twin data (DeFries and Fulker 1985, 1988) was fitted to spelling data from 100 pairs of MZ twins and 71 pairs of same-sex DZ twins tested in the Colorado Reading Project (DeFries, Olson, Pennington and Smith 1991), and to data from 12 pairs of MZ twins and 15 pairs of same-sex DZ twins tested in the London twin study of reading disability (Stevenson, Graham, Fredman and McLoughlin 1984, 1987). Estimates of hp2 fg obtained from analyses of these data suggest that about 60% of the deficit of probands is due to heritable influences in both samples. When a regression model was fitted separately to data from males and females in the combined Colorado and London samples, resulting estimates of hp2 fg were 0.66 ±0.18 and 0.56 ± 0.19, respectively, a nonsignificant difference. Collaborative analyses of data from additional twin studies of reading disability would facilitate more rigorous tests of hypotheses of differential genetic etiology as a function of group membership.

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