Abstract
Serotyping of five rabies virus isolates with monoclonal anti-nucleoprotein antibodies for classical rabies virus and rabies-related viruses and phylogenetic relationships among sequences indicate that viruses circulating in population of animals in Bosnia and Herzegovina belong to the sero-genotype 1 of classical rabies virus. Phylogenetic relationships among sequences of our viruses have shown the presence of two phylogenetic lines, one which is present in the northwestern part and other which is present in the northeastern part of the country. Our viruses are closely related to Westeuropean isolates of rabies virus.
Highlights
Rabies is an acute fatal zoonotic viral infection of the central nervous system that is transmitted by the bite of rabbit animals and is capable of infecting all warm-blooded species ( )
According to the valid taxonomy the genus Lyssavirus is classified into four serotypes and seven genotypes
After October, when the first fox rabies cases were found on the territory of the town Livno, wildlife rabies has become of increasing health and economic importance in Bosnia and Herzegovina ( )
Summary
Rabies is an acute fatal zoonotic viral infection of the central nervous system that is transmitted by the bite of rabbit animals and is capable of infecting all warm-blooded species ( ). The etiological agent of rabies- the rabies virus (order Mononegavirales, genus Lyssavirus, family Rhabdoviridae) is an RNA virus with a negatively polarized singlestranded RNA. According to the valid taxonomy the genus Lyssavirus is classified into four serotypes and seven genotypes. Despite continued attempts of prevention rabies is still present in many parts of the world. The most important reservoir of rabies in Europe is red fox, rabid animals having progressively moved from Eastern Europe after the Second World War and spread throughout Western Europe by the middle of the s ( ). After October , when the first fox rabies cases were found on the territory of the town Livno, wildlife (sylvatic) rabies has become of increasing health and economic importance in Bosnia and Herzegovina ( )
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