Genetic association study between Astrotactin-2 (ASTN2) rs10817999 gene polymorphism and attention deficit hyperactivity disorder in Korean children

Abstract

ASTN2 is an integral membrane protein whose role is necessary to neuronal migration's neural-glial adhesion. It has been reported its association of ASTN2 with attention deficit hyperactivity disorder (ADHD). ADHD is a heterogeneous disorder influenced by various environmental and genetic factors. Therefore, we analyzed the genetic association of ASTN2 rs10817999 and rs12376789, with ADHD in Korean children with ADHD and children without ADHD. A total of 472 samples (150 ADHD children and 322 controls) were analyzed in this study. There were no significant results of genotype and allele distribution in rs12376789. By contrast, rs10817999 showed significant genotype and allele frequency differences between the control and the cases (p = 0.003 and 0.001, respectively). The OR of ADHD children with the rs10817999 C/T genotype compare with control was 0.335 (95 % CI 0.126–0.893, p = 0.023) and rs10817999 T/T genotype compare with control was 4.406 (95 % CI 1.662–11.680, p = 0.001), and the OR with rs10817999 T allele versus C allele was 1.658 (95 % CI 1.217–2.260, p = 0.001). Significant associations were also observed in the dominant (p = 0.005) and the recessive (p = 0.008) genetic models. In the stratified analyses of ADHD subtypes and sex, we also observed a significant association of rs10817999 and ADHD (p < 0.05). In summary, we identified that the rs10817999 was associated with ADHD in Korean children. These findings may be used as a basis of replication in other ethnic groups or populations to clarify the possible role of this genetic variant in ADHD.