Abstract
This chapter discusses the genetic analyses of Pichinde and LCM arena viruses, offering evidence for a unique organization for Pichinde S RNA. Although the genome coding assignments for the three primary gene products of Pichinde viruses are known, the gene order of the S encoded proteins and their transcriptional strategies are unknown. The hydrophobic character of its amino proximal sequences could represent a signal or transmembranal region in common with other membrane, or secreted proteins. There is no U rich sequence following the N gene that could serve as a polyadenylation signal if a monocistronic N message is synthesized as, for example, in the case of rhabdoviruses. Alternatively, if there is a poly cistronic messenger in RNA species, it may be important in ribosome scanning or the initiation of the translation of the second gene product.
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