Abstract
Inserting genes from psychrophilic, or cold-loving, bacteria, into bacterial pathogens could prove a cool new way for developing vaccines, according to microbiologist Francis Nano at the University of Victoria, British Columbia, Canada, and his collaborators there and at the Rocky Mountain Laboratories in Hamilton, Mont. Under control of genes from psychrophiles, the pathogens grow only at relatively low temperatures but not at 37°C. Thus, the modified bacteria “grow in the skin, but do not penetrate deeper tissue and critical organs,” Nano says, staying there long enough to prime the host immune system but not long enough to cause disease. Details are described in the July 27, 2010 issue of the Proceedings of the National Academy of Sciences.
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