Abstract
Pax4 belongs to the paired-box family of transcription factors. The analysis of loss- and gain-of-function mutant animals revealed that this factor plays a crucial role in the endocrine pancreas. Indeed, Pax4 is required for the genesis of insulin-producing beta-cells. Remarkably, the sole misexpression of Pax4 in glucagon-expressing cells is able to induce their regeneration, endow these with beta-cell features, and thereby counter chemically induced diabetes. However, the function of Pax4 in adult endocrine cells remains unclear. Herein, we report the generation of Pax4 conditional knockout mice that will allow the analysis of Pax4 function in mature beta-cells, as well as in the adult central nervous system.
Highlights
Pax4 is a member of the paired-box-containing family of transcription factors (Mansouri et al 1996) that has been shown to play a crucial role in the endocrine pancreas (Sosa-Pineda et al 1997)
The analysis of the pancreas of Pax4-deficient animals demonstrated that this factor is an important player in the processes underlying beta-cell genesis (Sosa-Pineda et al 1997)
Further studies have evidenced that, during endocrine cell genesis, Pax4 is involved in the endocrine cell subtype specification
Summary
We report the generation of Pax4 conditional knockout mice that will allow the analysis of Pax4 function in mature beta-cells, as well as in the adult central nervous system. Pax4 is a member of the paired-box-containing family of transcription factors (Mansouri et al 1996) that has been shown to play a crucial role in the endocrine pancreas (Sosa-Pineda et al 1997). The analysis of the pancreas of Pax4-deficient animals demonstrated that this factor is an important player in the processes underlying beta-cell genesis (Sosa-Pineda et al 1997).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
