Abstract
The zebrafish embryo has been evaluated as an in vivo model for plasmonic nanobubble (PNB)generation and detection at nanoscale. The embryo is easily observed and manipulatedutilizing the same methodology as for application of PNBs in vitro. Injection andirradiation of gold nanoparticles with a short laser pulse resulted in generationof PNBs in zebrafish with similar parameters as for PNBs generated in waterand cultured living cells. These PNBs do not result in systemic damage, thus wedemonstrated an in vivo model for rapid and precise testing of plasmonic nanotechnologies.
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