Generalized scleroderma associated with chronic ulcerative colitis

Abstract

A case of generalized scleroderma associated with the clinical syndrome of non-specific ulcerative colitis is presented. The diagnosis was difficult to establish clinically and pathologically. The clinical course was characterized by a spectrum of collagen diseases that included systemic lupus erythematosus, rheumatic fever, rheumatoid arthritis, dermatomyositis and scleroderma. The patient received 11,000 units of ACTH, 48,000 mg. of hydrocortisone and 162,000 mg. of cortisone over a period of five years without significantly influencing the relentless course of the disease. The following complications of steroid medication developed: Cushing's syndrome and adrenal cortical atrophy, steroid psychosis, peptic ulcer and osteoporotic fractures of the vertebrae and humerus.