Abstract
A 38-year-old Japanese woman with steroid-dependent ulcerative colitis developed generalized pustular psoriasis. Cyclosporine improved both her cutaneous lesions and bowel condition. Recent studies show that Th17 T cells are critically involved in the pathogenesis of both generalized pustular psoriasis and inflammatory bowel disease. Although molecular mechanisms seem similar, our case is the first report showing generalized pustular psoriasis associated with inflammatory bowel disease. We believe that our case may contribute to further understanding of both diseases and give us a chance to design a suitable therapy in the case of generalized pustular psoriasis complicating inflammatory bowel disease.
Highlights
A 38-year-old Japanese woman with steroid-dependent ulcerative colitis developed generalized pustular psoriasis
Prednisolone was tapered and discontinued. We have continued this cyclosporine A (CSA) dose for 2 years, because her bowel condition may deteriorate if we reduce it
Generalized pustular psoriasis (GPP) is a rare but severe cutaneous disease, characterized by a sudden generalized eruption of sterile pustules on a highly erythematous skin surface accompanied by a high fever [1]
Summary
A 38-year-old Japanese woman with steroid-dependent ulcerative colitis developed generalized pustular psoriasis. A 38-year-old Japanese woman, without history of psoriasis and other skin disorders, presented with pustules and erythematous papules on her extremities. Because her bowel condition got worse, her doctor raised the prednisolone dose from 8 mg/day to 30 mg/day. After her bowel condition stopped worsening, he administered azathioprine and reduce her prednisolone dose to 20 mg/day.
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