Abstract
The basis of pharmacokinetics rests on certain assumptions of compartmentalization in the body and of the general permeability properties of the tissue and cell membranes. The rate constants in the compartment kinetics is most commonly defined as a Fick's diffusion constant, where the concentration gradient is the driving force. Although this type of assumption has been quite successful in an increasing number of practical applications (elaborated by analog or digital computation technique) it seems necessary to reevaluate in a more profound manner the mechanisms of transport in biological systems. The general laws governing membrane transport of molecules and ions will be reviewed within the framework of the following general formulation:
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