General Approach for the synthesis of macroline/sarpagine related indole alkaloids Via the asymmetric pictet-spengler reaction: the enantiospecific synthesis of the N a-H, azabicyclo[3.3.1]nonone template

Abstract

N a-H, N b-benzyltetracyclic ketone 1a, a potential intermediate for the synthesis of numerous sarpagine-related alkaloids, has been synthesized enantiospecifically from D-(+)-tryptophan via the asymmetric Pictet-Spengler reaction.