General and local stomatological and immunogenetic changes with undifferentiated connective tissue dysplasia

Abstract

BACKGROUND: Works devoted to the study of homocysteine metabolic disorders in undifferentiated connective tissue dysplasia and the dental condition of patients with undifferentiated connective tissue dysplasia were not found in the available literature. The consideration of etiological factors, some pathologies of oral tissues associated with connective tissue dysplasia, specificity of clinical courses, diagnosis, differential diagnosis, prevention, and treatment have no unified approaches, which is the main reason for inadequate proper medical and dental care for patients.
 AIM: This study aimed to examine the dental and immunogenetic state of the oral cavity and the body as a whole in the surveyed people with undifferentiated connective tissue dysplasia.
 MATERIAL AND METHODS: The present study is based on the data obtained from the observation of 48 patients in 20162020 with undifferentiated connective tissue dysplasia and chronic generalized periodontitis (main group) and 34 patients without signs of musculoskeletal dysplasia but diagnosed with chronic generalized periodontitis (control group) aged 1837 years.
 RESULTS: The average dental caries intensity was 16.7 in the studied group of patients with AH. The following is the ratio of Caries Filling Extraction Index elements: caries of 2,1; fillings of 13,3; extracted teeth of 3,2 out of 26:1 teeth; non-carious dental lesions of 4,5; and periodontal tissue pathology of 85,5. Alveolar bone resorption values in the upper and lower jaws of female patients aged 3037 showed that bone loss in the alveolar process of the upper jaw is a bit faster (69%) than in the lower jaw (45%) (p 0.3).
 CONCLUSION: The state of dental hard tissue on the background of reduced bone mineral density is characterized by the high intensity of the carious process and a significant number of extracted teeth. Disbalance in the calcium-regulating hormone system in patients with undifferentiated connective tissue dysplasia of middle age of both sexes promotes the development of an aggressive disease course, which is determined by reliably significant periodontal indexes worsening, increased attachment loss, and a higher bone tissue resorption degree.