Abstract
Gene-altered Mice and Metabolic Flux Control
Highlights
In mammals, the opposing processes of glycolysis and gluconeogenesis are both essential for glucose homeostasis
While they are co-expressed in the liver, periportal and perivenous hepatocytes possess different amounts of these and other glycolytic and gluconeogenic enzymes, and different metabolic capaci
The cytoplasmic PEPCK isoform is found in the proximal tubule of the kidney, adipose, and intestine, in addition to hepatocytes [10]
Summary
The opposing processes of glycolysis and gluconeogenesis are both essential for glucose homeostasis. In both the liver and kidney this enzyme has long been thought to play a role in determining gluconeogenic flux, the gene is regulated differently in these two sites [10, 11].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
