Abstract
Chromatin Remodeling and the Control of Gene Expression
Highlights
Biochemical and genetic findings accumulated over the past decade have established that the condensation of eukaryotic DNA in chromatin functions to constrain the genome within the boundaries of the cell nucleus and to suppress gene activity in a general manner
Histone Acetylation Since the early discovery of histone acetylation by Allfrey and colleagues [13], this post-translation modification has been correlated with the processes of transcription and chromatin assembly
Acetylation occurs at specific lysines in the flexible N-terminal histone tails that protrude from the nucleosome surface [11, 14]
Summary
Biochemical and genetic findings accumulated over the past decade have established that the condensation of eukaryotic DNA in chromatin functions to constrain the genome within the boundaries of the cell nucleus and to suppress gene activity in a general manner. The catalytic domain of the Gcn5 HAT is required for coactivator function in vivo, providing a genetic link between histone modification and transcriptional activation [23].
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