Abstract
The exposure to a uv laser microbeam can modify a selected portion of cell membrane to be temporarily permiative, thereby allowing a foreign substance to enter living cell. As a first application of laser microbeam to the field of bionicis, the method was employed in incorporating the exogenous gene into cells. The method was found to offer a marked advantage over the existing ones in the success rate of gene incorporation, effi-ciency to large throughput, and in versatility to broad cell-type.
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