Abstract
Obsessive-Compulsive Disorder is one of the complex mental disorders that combination of genetic components and environmental factors influence its phenotype. In this study, data from microarray findings has been evaluated from gene ontology perspective. The raw data from GEO was at first analyzed by the use of GEO2R Software as two groups of samples (Normal/OCD and Normal/ OCD with comorbidity); and then enrichment analysis of 50 significant differentially expressed genes of each group of samples was handled. The data indicates that enrichment findings in two groups are relatively similar. Furthermore, regulation of transcription, plasma membrane, and nucleotide and ion bindings are the most involved processes, parts and functions, respectively. In conclusion, these terms can be introduced as potential representations in OCD risk; however, clinical validations are required and suggested. Thus, for this aim, systematic molecular studies, particularly in the field of proteomics and metabolomics are fundamental.
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