Abstract
Many studies have shown that microRNAs could play a role as predicting biomarkers. The aim of this study is investigation of predictive role of miR-126 in type 2 diabetic Mellitus (T2DM) patients. Eligible studies were selected from PubMed, MEDLINE, EMBASE, Science Direct, ProQuest databases and the information of these studies were extracted. The meta-analysis tests of standardized mean differences (SMD) with 95% confidence interval (95% CI), summary odds ratio, heterogeneity and publication bias performed using comprehensive meta-analysis version 3.0 (CMA) and STATA12 statistical analysis software. This meta-analysis included 6 studies association with circulating miR-126 in T2DM. Concentration of circulating miR-126 was lower with SMD (-0.131) (95% CI (-0.237) - (-0.025)) p-value (p= 0.016). The summary diagnostic odds ratio circulating miR-126 was (0.787) (95% CI (0.650) - (0.953)) and also sensitivities value was (42%) with a 5% false positive rate. I2= 0.00% and p= 0.5 indicating that non-significant heterogeneity between studies. Results of this study indicated that circulating miR-126 may be as a useful marker for accurate prediction of type 2 diabetes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
