Abstract
ABSTRACT Ten-week-old Langde geese in similar body weight were randomly selected, four for overfeeding and four for routinly feeding. The abundance of liver fatty acid-binding protein (L-FABP), thyroid hormone-responsive (THRSP or Spot 14), obese (OB), and apolipoprotein A1 (Apo A1) genes in goose were detected by quantitative RT-PCR. L-FABP was higher expressed in liver and intestine than other tissues, but no expression was detected in the pancreas or brain. The other three genes were widely expressed in different tissues, OB was higher expressed in pancreas and abdominal fat, Spot 14 and Apo A1 was higher expressed in sebum and abdominal fat. Spot 14 and Apo A1 genes were up-regulated in overfed goose livers compared with that in the control. Thus, Spot 14 and Apo A1 genes may play important roles in lipid metabolism in goose fat liver.
Highlights
Fatty acid-binding proteins (FABPs) play important roles in the transport of fatty acids from the plasma membrane to the sites of β oxidation or/and triacylglycerol or phospholipid synthesis (Veerkamp et al, 1995)
liver-type FABP (L-FABP) gene was found to be highly expressed in the liver and intestine and expressed in various tissues
No L-FABP expression was detected in the pancreas or brain
Summary
Fatty acid-binding proteins (FABPs) play important roles in the transport of fatty acids from the plasma membrane to the sites of β oxidation or/and triacylglycerol or phospholipid synthesis (Veerkamp et al, 1995). The L-FABP gene was highly expressed in the liver, and L-FABP gene-knock-down rats had significantly lower transportation of fatty acids compared with the control (Wang et al, 2006). The thyroid hormone-responsive (THRSP or Spot 14) gene was determined to be highly expressed in the liver of chicken and expressed in fat tissues (Wang et al, 2002). Spot 14 expression was associated with the expression of the thyroid hormone (Wang et al, 2002). We selected several important genes related to lipid metabolism, Ma YF, Chen L, He J, Tian Y, Xu XQ, Du X, Lu LZ. We detected the expression patterns of these genes in different tissues and determined their differences between control and overfed (OF) geese
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