Gender Effect on Some Blood Parameters in Patients Undergoing Haemodialysis in North Western Algeria

Abstract

Replacement therapy for chronic kidney disease using haemodialysis involves the elimination of excessive toxic fluids and toxic metabolic end products from the body. Worldwide, gender significant differences exist with regard to the epidemiological aspect, evolution and blood parameters of chronic renal failure disease. In the present retrospective study, 289 medical files of adult patients (154 men and 135 women) aged 20 to 78 years were investigated to understand the relationship between gender difference and blood parameters in patients with chronic renal failure undergoing haemodialysis in north western Algeria. Our results revealed significant higher levels of haemoglobin (p=0.003), haematocrit (p=0.005), creatinine (p<0.001) and uric acid (p=0.037) in men comparing to women. However, women serum samples were characterized by higher significant level of platelets (p=0.002). No significant differences (p˃0.005) were observed between the two genders regarding the other parameters of blood count formula, liver function parameters, urea, mineral status (calcemia and phosphoremia), basic biochemical levels (glycaemia and lipids), C-reactive protein (CRP) and parathyroid hormone (PTH). In dialysis patients, and despite the fact that some serum parameters vary significantly, the majority of the parameters recorded were often high in the males compared to the female gender. This finding may be due to the existence of specific confounding prognostic factors for each sex, which may or may not compensate for each other, therefore, ultimately, leading to overall non-significance.