Gender Differences in Trace Element and Lipid Levels in Patients with Vitamin D Deficiency or Insufficiency

Abstract

A total of 124 adults with vitamin D deficiency or deficiency were recruited to investigate the plasma levels of 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3), 25-hydroxyvitamin D3 (25(OH)D3), trace elements (Mg, Fe, Zn, Cu) and blood lipids (TC, TG, LDL-C, HDL-C). This article also explores the relationship among vitamin D, trace elements, and blood lipids. Results: 1. The 25(OH)D3, BMI and TG levels of male patients were higher than those of female patients, while the HDL-C levels were lower, with significant differences (<I>P</I> < 0.01, <I>P</I>=0.026, <I>P </I>< 0.001, <I>P</I> < 0.001). The level of 1,25(OH)2D3 in male patients was higher than that in female patients, and the PTH was lower, but there was no statistical difference <i>(P</i>> 0.05). The concentrations of Mg, Zn and Fe in male patients were higher than those in female patients, with statistical differences (<I>P</I><0.001, <I>P</I>=0.01, <I>P</I>=0.014), while Cu in female patients was higher, but no statistical difference (<I>P </I>> 0.05). 2. 1,25(OH)2D3 was positively correlated with Fe (r=0.267, <I>P</I> < 0.05). Fe was positively correlated with Mg and Zn (r=0.321, <I>P</I> < 0.001; r=0.341, <I>P</I><0.001). 1,25(OH)2D3/25(OH)D3 was negatively correlated with TC, TG and LDL-C (<I>P</I><0.05), but had no correlation with HDL-C (<I>P</I> > 0.05). There was a negative correlation between Fe and TG in male patients (r= -0.377, <I>P</I>=0.033), but no significant correlation between Fe and blood lipid in female patients (<I>P </I>> 0.05). Zn was positively correlated with TC and TG in female patients (r=0.238, <I>P</I>=0.022; r=0.255, <I>P</I>=0.014), and there was no significant correlation between Zn and blood lipid, Mg and Cu (<I>P </I>>0.05). Conclusions: 1. The vitamin D3 and trace elements of female patients are lower than those of male patients, so they need to supplement vitamin D and trace elements more, while male patients need to pay more attention to the management of BMI and blood lipid. 2. The interaction between vitamin D, trace elements and blood lipid.