Abstract
IntroductionColor processing is a central component of mammalian vision. Gender-related differences of color processing revealed by non-invasive functional transcranial Doppler ultrasound suggested right hemisphere pattern for blue/yellow chromatic opponency by men, and a left hemisphere pattern by women.Materials and MethodsThe present study measured the accumulation of [18F]fluorodeoxyglucose ([18F]FDG) in mouse brain using small animal positron emission tomography and magnetic resonance imaging (PET/MRI) with statistical parametric mapping (SPM) during light stimulation with blue and yellow filters compared to darkness condition.ResultsPET revealed a reverse pattern relative to dark condition compared to previous human studies: Male mice presented with left visual cortex dominance for blue through the right eye, while female mice presented with right visual cortex dominance for blue through the left eye. We applied statistical parametric mapping (SPM) to examine gender differences in activated architectonic areas within the orbital and medial prefrontal cortex and related cortical and sub-cortical areas that lead to the striatum, medial thalamus and other brain areas. The metabolic connectivity of the orbital and medial prefrontal cortex evoked by blue stimulation spread through a wide range of brain structures implicated in viscerosensory and visceromotor systems in the left intra-hemispheric regions in male, but in the right-to-left inter-hemispheric regions in female mice. Color functional ocular dominance plasticity was noted in the right eye in male mice but in the left eye in female mice.ConclusionsThis study of color processing in an animal model could be applied in the study of the role of gender differences in brain disease.
Highlights
MethodsThe present study measured the accumulation of [18F]fluorodeoxyglucose ([18F]FDG) in mouse brain using small animal positron emission tomography and magnetic resonance imaging (PET/MRI) with statistical parametric mapping (SPM) during light stimulation with blue and yellow filters compared to darkness condition
Color processing is a central component of mammalian vision
positron emission tomography (PET) revealed a reverse pattern relative to dark condition compared to previous human studies: Male mice presented with left visual cortex dominance for blue through the right eye, while female mice presented with right visual cortex dominance for blue through the left eye
Summary
The present study measured the accumulation of [18F]fluorodeoxyglucose ([18F]FDG) in mouse brain using small animal positron emission tomography and magnetic resonance imaging (PET/MRI) with statistical parametric mapping (SPM) during light stimulation with blue and yellow filters compared to darkness condition. Five male and five female CD-1 mice (10–12 weeks, male = 34 ± 2.8 g; female = 26 ± 1.7 g) (received from the facility of the University of Leipzig, Medizinisch-Experimentelles Zentrum) were housed under a 12 hour light: 12 hour dark cycle at 24 ̊C, 60% humidity in a vented temperature-controlled animal cabinet (HPP110, Memmert GmbH & Co. KG; Schwabach, Germany), with free access to food and water. The same animals were repeatedly imaged with PET on consecutive days without randomization to keep the daytime of measurement (e.g. the glucose/insulin levels) constant.
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