Abstract
The purpose of this study was to develop a suitable gelatin-based formulation for topical delivery. Eight films (F1-F8) were prepared by solvent evaporation method using different polymers in different variety such as gelatin as main compound, methyl cellulose, carboxymethyl cellulose and gellan gum. Thickness, moisture uptake, irritation profile, cytotoxicity, adhesiveness, transepidermal water loss, barrier function and physicochemical properties and skin adhesion of five formulations (F1-F8) were characterized. Furthermore, PVP-iodine was incorporated in the formulations and drug concentration uniformity, drug release antibacterial activity and drug release were investigated. All eight gelatin-based formulations F1-F8 were found nonirritant and showed over 85% cell viability after 24 h. F5 comprising gelatin (0.05%) and methylcellulose (MC) indicated 4.91-fold skin adhesion compared to F8 without MC. F5 indicated 1.67-fold elongation behavior compared to L8 without MC. Furthermore, F5 provided highest drug concentration uniformity. Moreover, the antimicrobial activity ranking of formulations was L3, L1 > L2 > L5 > L7 > L8, L4 > L6 against E. coli. These findings indicated that PVP-iodine containing films were suitable for the treatment of wound management. In summary, we have demonstrated that adhesive gelatin-based formulations present a promising topical drug delivery system.
Published Version
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