Abstract
Purple tea (PT) is a high-antioxidant tea variety that is rich in anthocyanin. The rich purple color and antioxidant nature of the drink have provoked several studies on the plant. Some studies highlight the therapeutic potential of the plant. In this paper, we performed phytochemical and polypharmacological studies on samples collected from Barnesbeg Tea Garden, Darjeeling, India. We have employed in silico reverse pharmacology and a target-fishing approach to comprehend the full potential of PT in various disease management. Twenty-nine phytocompounds were obtained in the Gas Chromatography-Mass Spectrometry analysis of PT leaves. Antioxidant property assessment of PT through DPPH radical scavenging activity and FRAP assay showed much higher activity than standards, ascorbic acid, and BHT, respectively. The total phenol and flavonoid were quantified as 19.36 ± 0.44 mg GAE/g and 571.801 ± 1.44 mg QE/g of extract, respectively. It was found to target pathways such as the ErbB signaling pathway, PPAR signaling pathway, Insulin signaling pathway, Ras signaling pathway, Natural killer cell-mediated cytotoxicity, Neurotrophin signaling pathway, etc. This is the first study on target fishing and network pharmacology of PT. Thus, the study exhibited PT's role and probable mechanism of action against type-2 Diabetes, Hyperlipidemia, Coronary Heart Disease, Cancer-related impediments, and other lifestyle disorders.
Published Version
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