Abstract
The oral route is the best and most popular route for the administration of drugs in the systemic circulation. There are number of drugs which are given through the oral route. Gastro-retentive drug delivery system is very important system for the drug delivery system. The gastro-retentive drugs prolonged the drug time in the git and also improve their their bioavailability. These are widely used for site specific for the treatment of git disorders and diseases. There are number of approaches for gastro retentive drug delivery system such as floating system, mucoadhesive system, swelling system, high density system etc. In this review we discussed about approaches and various perspectives of gastro retentive drug delivery system.
Highlights
In this review we discussed about approaches and various perspectives of gastro retentive drug delivery system
The most popular route for drug administration is oral route for systemic action .About 90% of the drugs are given by oral route
Expanding/swelling system These dosage form after administrated to such an extent that it prevents to passage through the pyrolus, as a result the dosage form is remained in the stomach for a prolong period of time (Figure 9)
Summary
The most popular route for drug administration is oral route for systemic action .About 90% of the drugs are given by oral route. Effervescent system When these drugs come in contact with gastric juice of stomach, carbondioxide gas is released .This provide buoyancy to the dosage form that float on the gastric fluid. These effervescent system have further divided into different types: 9.2. Expanding/swelling system These dosage form after administrated to such an extent that it prevents to passage through the pyrolus, as a result the dosage form is remained in the stomach for a prolong period of time (Figure 9) These system are called as plug type system because they remain have the tedency to lodged at the pyrolic sphincter. The extensive swelling of these polymers is a result of the presence of physical-chemical crosslinks in the hydrophillic polymer network [26, 27]
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