Abstract
Gastro protective effects of aqueous Carica papaya seed extract on ethanol induced gastric ulcer were investigated in male rats. Thirty two (32) male rats weighing between 180 and 250 g were randomly divided into four groups. Group 1 served as the negative control (distilled water), groups 2 and 3 received 50mg/kg and 100mg/kg Carica papaya seed extract respectively, while group 4 received 200mg/kg cimetidine (positive control). Two weeks after the oral administration, gastric ulcer was induced in all rats with ethanol (1 ml of 80% orally). Gastric juice volume, gastric acidity, ulcer index and percentage ulcer inhibition were determined. The results showed that the extract protected the gastric mucosa against ethanol effect. C. papaya extract significantly reduced the gastric juice volume and gastric acidity (p<0.05) in dose dependent manner when compared with the control. The percentage ulcer inhibition was significantly high (p<0.05) in rats treated with the extract when compared with the control and the effect is similar to that of rats treated with cimetidine. This study shows that C. papaya seed extract may possess gastro protective effects against ethanol induced gastric ulcer in male rats.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
