GASTROINTESTINAL STROMAL TUMOUR – EXPERIENCE OF A PERIPHERAL TERTIARY CARE INSTITUTE

Abstract

Introduction- GIST is a generally a rare tumour but it is most common mesenchymal malignancy of gastrointestinal tract . this malignancy originates from the interstitial cells of Cajal, the pacemakers of GI tract. Management of GIST is associated with difculties at diagnosis, proper immunohistochemical categorisation, completeness surgical excision,resistance to available TKIs. Aim of this study was to share the experience of treating GIST case AIMS - Methods- s from a peripherally located tertiary level hospital . In this retrospective observational study all the histology and immunohistochemistry proved cases of GIST attending Department of Radiotherapy of Midnapore Medical College between 2016 to 2017 were accrued and evaluated. 12 Cases were evaluated for their Result - demographic character, clinical presentation , treatment history, response pattern. M:F ratio was 1.4:1.Age range was 37 years to 58 years. Eleven cases were postoperative and 1 case was advanced inoperable. All the cases were positive for KIT stains .All the patients received treatment with Tyrosine Kinase inhibitor Imatinib Mesylate. At the end of 2 yrs of treatment and follow up 10 patients were disease free , two patients developed progression of disease. Introduction of Imatinib Mesylate and other TKIs have Conclusion - revolutionised the management of GISTs. Still the management is associated different obstacles like early diagnosis, proper immunohistochemical and genotypic categorisation, resistance to available TKIs , lack of large scale studies . Further long term studies with larger study population is needed to improve the treatment outcome of patients suffering from this mysterious disease.