Abstract
Gastrodia elata Blume (Orchidaceae) is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the potential analgesic effect of its active component, gastrodin, has not been systematically studied. This work described the anti-hyperalgesic effect of gastrodin in a mouse model of chemotherapeutic agent vincristine-induced neuropathic pain. Gastrodin (0.05-0.8 mg/kg) dose-dependently reverted the mechanical hyperalgesia in mice. In addition, the anti-hyperalgesic effect of gastrodin was significantly blocked by a selective serotonin 5-HT 1A receptor antagonist WAY100635 (1 mg/kg). In contrast, gastrodin did not significantly alter the general locomotor activity in mice. Taken together, this study demonstrated that gastrodin possesses robust analgesic efficacy in mice and may be a novel analgesic for the management of neuropathic pain. DOI: http://dx.doi.org/10.3329/bjp.v8i4.16836 Bangladesh Journal of Pharmacology Vol.8(4) 2013 414-419
Highlights
Chemotherapy-induced peripheral neuropathy has been increasingly recognized as a serious side effect associated with several commonly used chemotherapeutic agents, including taxanes, platinum agents, and vinca alkaloids during cancer treatment
Vincristine treatment (0.5 mg/kg) for 5 days led to marked mechanical hyperalgesia in mice as measured by von Frey filament (Figure 1)
We reported that an active component from the plant G. elata, gastrodin, produced robust antihyperalgesic effect in a mouse model of chemotherapyinduced neuropathic pain
Summary
Chemotherapy-induced peripheral neuropathy has been increasingly recognized as a serious side effect associated with several commonly used chemotherapeutic agents, including taxanes, platinum agents, and vinca alkaloids (e.g., vincristine) during cancer treatment. Depending on the treatment regimens, chemotherapy-induced neuropathic pain can occur in 30-40% of patients and even as high as 75% under certain regimens. Motor symptoms include weakness and gait and balance disturbances (Visovsky et al, 2007). In most cases, this kind of neuropathic pain is only partially reversible with cessation of treatment and in the worst cases damage can be permanent. There is no one drug or drug class that is considered safe and effective for treatment of chemotherapy-induced neuropathic pain, making the development of alternative effective analgesics a crucial clinical need. We described the potent antinociceptive effects of gastrodin in a mice model of vincristine-induced neuropathic pain. Gastrodin, suggesting that the observed antinociceptive effect of gastrodin was partially media-ted by 5-HT1A receptors
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