Abstract
Common chemotherapeutic agents such as oxaliplatin often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is difficult to treat and responds poorly to common analgesics, which represents a challenging clinical issue. Corydalis yanhusuo is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the potential analgesic effect of its active component, levo-tetrahydropalmatine (l-THP), has not been reported in conditions of neuropathic pain. This study found that l-THP (1–4 mg/kg, i.p.) produced a dose-dependent anti-hyperalgesic effect in a mouse model of chemotherapeutic agent oxaliplatin-induced neuropathic pain. In addition, we found that the anti-hyperalgesic effect of l-THP was significantly blocked by a dopamine D1 receptor antagonist SCH23390 (0.02 mg/kg), suggesting a dopamine D1 receptor mechanism. In contrast, l-THP did not significantly alter the general locomotor activity in mice at the dose that produced significant anti-hyperalgesic action. In summary, this study reported that l-THP possesses robust analgesic efficacy in mice with neuropathic pain and may be a useful analgesic in the management of neuropathic pain.
Highlights
Common chemotherapeutic agents such as oxaliplatin often cause neuropathic pain during cancer treatment in patients
When the dose of l-THP was further increased to 4 mg/kg, the paw withdrawal threshold was significantly increased to the pre-oxaliplatin treatment level (Fig. 2).Two-way analysis of variance (ANOVA) revealed a significant main effect of l-THP treatment (F [1, 63] 5 76.45, P, 0.0001)
In this study, we reported that an active component from the plant Corydalis yanhusuo, l-THP, produced robust anti-hyperalgesic effect in a mouse model of chemotherapy-induced neuropathic pain
Summary
Common chemotherapeutic agents such as oxaliplatin often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is difficult to treat and responds poorly to common analgesics, which represents a challenging clinical issue. This study found that l-THP (1–4 mg/kg, i.p.) produced a dose-dependent anti-hyperalgesic effect in a mouse model of chemotherapeutic agent oxaliplatin-induced neuropathic pain. Motor symptoms are reported, including weakness and gait and balance disturbances1 This kind of neuropathic pain is only partially reversible even long after the cessation of treatment and in some rare cases damage can be permanent. We described the potent anti-hyperalgesic effect of l-THP in a mice model of oxaliplatin-induced neuropathic pain. Our results revealed a primary dopamine D1 receptor mediated effect
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