Abstract
Various efforts have been undertaken to enhance the bioavailability and clinical performance of oral drug formulations. In pursuit of improving the therapeutic effectiveness of medications that are susceptible to degradation in alkaline pH environments, possess a limited window for absorption within the stomach, and readily dissolve under acidic conditions, a diverse range of gastro-retentive drug delivery systems (GRDDS) have been innovatively designed and developed. As a result, the stomach’s physiological state and the various factors that influence GRDDS will be discussed. As a rule, this survey will enlighten and coordinate enumerating scientists in arranging, plan, and planning the GRDDS.
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