Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori infection: a review of current diagnosis and management.

Qinglong Hu,Xiaoyan Zhang,Yizhuo Zhang,Kai Fu

doi:10.1186/s40364-016-0068-1

Abstract

Helicobacter pylori (H. pylori)-associated gastritis is one of the most common infectious diseases in the United States, China and worldwide. Gastric mucosa-associated tissue lymphoma (MALT lymphoma) is a rare mature B-cell neoplasm associated with H. pylori infection that is curable by antibiotics therapy alone. The pathological diagnosis of gastric MALT lymphoma can be reached by histological examination, immunohistochemical staining and B-cell clonality analysis. H. pylori eradication is the choice of therapy for early-stage gastric MALT lymphoma. High response rates and long-term survival have been reported in refractory and localized diseases treated with low-dose radiation therapy. Systemic chemotherapy is recommended for advanced-stage gastric MALT lymphoma and cases with large B-cell lymphoma transformation. Recent advances in the pathological diagnosis and management of gastric MALT lymphoma are reviewed in this article.

Highlights

Helicobacter pylori (H. pylori) infection of the stomach is one of the most common diseases worldwide
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a neoplasm associated with H. pylori infection and is the first malignant disease that can be cured by antibiotics therapy alone
The estimated incidence of gastric MALT lymphoma is low (0.3-0.4/ 100,000) in the United States and Europe, but the incidence is not known in China

Summary

Introduction

Helicobacter pylori (H. pylori) infection of the stomach is one of the most common diseases worldwide. We searched literature of studies of H. pylori gastritis and gastric MALT lymphoma in English and Chinese and reviewed the recent advances in the diagnosis and management of these two closely related diseases. H. pylori-associated chronic active gastritis is present in the majority of patients with gastric MALT lymphoma. Histopathologic features of gastric MALT lymphoma Under microscopic examination, the biopsy tissue usually shows dense lymphoid infiltration with monotonous features.

Results

Conclusion