Abstract
Gasotransmitters have proven to have crucial regulating effects on a variety of physiological processes, triggering the vigorous development of gas-mediated therapeutics. These gaseous molecules have also showed potent therapeutic effects on bacterial infections due to their unique antibacterial and anti-biofilm mechanisms. Due to the dose-dependent physiological actions of gasotransmitters, the controlled location and duration of gas release are key to antibacterial effects. However, delivering gasotransmitters by directly administrating gaseous molecules or small molecular donors lack both controllability and tissue specificity, leading to side effects. In order to maximize the antibacterial effects of gasotransmitters, multifunctional polymeric nanomaterials are usually utilized for effective gas loading, targeted gas delivery and controlled gas release. Moreover, due to the bacteria-sensitizing property of gasotransmitters, co-delivery of gasotransmitters can synergistically enhance the effects of other antibacterial therapeutics. This article will summarize the recent progress in gasotransmitter-releasing polymeric nanomaterials in antibacterial therapeutics.
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