Abstract
Background and Aims : Gasdermin D (Gsdmd) is a key executioner of NLRP3 inflammasome- and caspase 1-dependent pyroptotic cell death. Recently, expression of Gsdmd and caspase 1-mediated cleavage of Gsdmd was described in atherosclerotic plaques. Plaque rupture is associated with strong immunoreactivity for caspase 1, suggesting that Gsdmd-mediated pyroptosis and inflammation are involved in plaque destabilization. Therefore, we aimed to study the effects of Gsdmd deficiency on advanced plaques in ApoE-/- mice.
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