Abstract

In the pharmaceutical production it has a vital importance to determine and control the concentrations of gases involved in the fermentation process. Conventional methods are specific or difficult to handle and a quadrupole mass spectrometer with a sampling unit devised for this purpose proved to be the optimum means for measuring the concentrations of both the exit gases and the gases dissolved in the fermentation broth. The measuring system and examples of mass spectrometric monitoring of fermentation gases are presented.

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