Abstract
A gas chromatographic—mass spectrometric procedure for the quantitation of urinary 11-nor-Δ 9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) has been developed in which the THC-COOH was derivatized to its corresponding methyl ester—methyl ether derivative by direct extractive alkylation using tetrahexylammonium (THA +) counter-ion and iodomethane dissolved in toluene. The procedure utilised a sample volume of 2 ml and gave a detection limit of 0.25 ng/ml. The inter-run and intra-run coefficients of variation were 7.0% and 4.8%, respectively. The inter-day standard curves were linear in the concentration range 0–300 ng/ml with a mean r = 0.9997 ( n = 4).
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Schedule a callMore From: Journal of Chromatography B: Biomedical Sciences and Applications
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