Garlic oil loaded rosuvastatin solid self-nanoemulsifying drug delivery system to improve level of high-density lipoprotein for ameliorating hypertriglyceridemia

Abstract

Objective of study was to develop a solid self-nanoemulsifying rosuvastatin drug delivery system (S-SNEDDS) for enhancement of its oral bioavailability and to produce synergistic action with garlic oil for better management of hypertriglyceridemia. Results showed that mean globule size of all reconstituted self-nanoemulsifying drug delivery system (SNEDDS) was found to be in nanometric range (48.32–73.64 nm) with optimum polydispersibility index (PDI) values (0.215–0.448). Rosuvastatin release from SNEDDS formulae in vitro showed that more than 75% of rosuvastatin released in about 30 min. Optimized SNEDDS formulae were selected for use with spray drying technique to develop into S-SNEDDS. Rosuvastatin plasma concentrations in rats treated with S-SNEDDS have been found at all times to be substantially high. When garlic oil-loaded rosuvastatin S-SNEDDS was administered orally to poloxamer-407 (P-407) induced hypertriglyceridemia rats there was significant (p ˂ 0.01) more increase in high-density lipoprotein (HDL) (19.24 ± 0.40 mg/dl) in comparision to rosuvastatin commercial tablet treated group. Rosuvastatin commercial tablet treated group showed significantly (p ˂ 0.01) less PT and APTT as compared to garlic oil loaded rosuvastatin S-SNEDDS treated group. Findings showed that garlic oil loaded rosuvastatin S-SNEDDS might play important role in better management of hypertriglyceridemia.