Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies.

Minnu Sasi,Mohamed Mekhemar,Marisennayya Senapathy,Surinder Singh,Sandeep Kumar,Deepak Chandran,Sandhya Thapa,Vivek Saurabh,Anitha Thiyagarajan,Yamini Tak,Suraj Prakash,Muzaffar Hasan,Uma Prajapati,Ahmad Alhariri,Abhijit Dey,Shweta Kumari,Sangram Dhumal,Sushil Changan,Ashok Kumar,Manoj Kumar,R Pandiselvam ,Sneh Punia ,Radha

doi:10.3390/antiox10111847

Abstract

Garlic (Allium sativa L.) is a bulbous flowering plant belongs to the family of Amaryllidaceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garlic have been investigated for their role in oral health, which are ascribed to a myriad of biologically active compounds such as alliin, allicin, methiin, S-allylcysteine (SAC), diallyl sulfide (DAS), S-ally-mercapto cysteine (SAMC), diallyl disulphide (DADS), diallyl trisulfide (DATS) and methyl allyl disulphide. A systematic review was conducted following the PRISMA statement. Scopus, PubMed, Clinicaltrials.gov, and Science direct databases were searched between 12 April 2021 to 4 September 2021. A total of 148 studies were included and the qualitative synthesis phytochemical profile of GE, biological activities, therapeutic applications of garlic extract (GE) in oral health care system, and its mechanism of action in curing various oral pathologies have been discussed. Furthermore, the safety of incorporation of GE as food supplements is also critically discussed. To conclude, GE could conceivably make a treatment recourse for patients suffering from diverse oral diseases.

Highlights

Natural products and traditional medicines are of substantial importance
Ajoene and 2-VD showed higher antioxidant activity compared to diallyl sulfide (DAS), diallyl disulphide (DADS) and diallyl trisulfide (DATS)
Ajoenes and 2-VD showed higher antioxidant activity compared to DAS, DADS and DATS

Summary

Introduction

Natural products and traditional medicines are of substantial importance. Modern medicine may not be the sole antidote for the ailments prevailing today. People positively perceive ‘back to nature’ approaches like phytotherapy as plant products are rich in pharmaceuticals [1,2,3]. Allium sativum, which is well-known as garlic, belongs to the family Amaryllidaceae. It has been known to humankind for many ages for its bioceutical properties. Garlic is indigenous to central Asia and has long been an important crop in the Mediterranean region and as seasoning in continents like Africa and Europe. India ranks second in garlic production, where the first is China [4]

Methods

Results

Conclusion