Garcinia mangostana L. fruit rind extract in ethyl acetate, n- butanol and water fractions: phytochemical analysis, antioxidant assay and cytotoxicity assay

Abstract

The aim of the study is to investigate the relationship between the phytochemical content of the fruit rind of Garcinia mangostana Linn with antioxidant activity and cytotoxicity of different fractions (ethyl acetate, n-butanol, water) of the xanthones extract. The ethyl acetate fraction showed the highest total xanthones as quercetin equivalent and α-mangostin equivalent, total xanthones as a-mangostin, and, total polyphenol content. High antioxidant activity and cytotoxicity were also shown from the ethyl acetate fraction with 55.8 μg/ml and 0.0029 μg/ml for IC50 and LC50 values, respectively. The linear correlations were confirmed between the total phenolic content and antioxidant activity as well as cytotoxicity of the xanthones extracts. The results of bioactivity assays and photochemical analysis of different fractions of xanthones extract showed that the ethyl acetate fraction of xanthones extract can be considered as a promising source of anticancer bioactives to be used in controlled release formulations.