Abstract
Gangliosides, glycosphingolipids with sialic acid, were found in metacestodes of Echinococcus multilocularis in low quantities. All gangliosides were resolved after preparative high-performance thin layer chromatography into four fractions. Cholera toxin was specifically bound to the major gangliosides, allowing the identification of it as a G M1. Precise structure of the four fractions was determined by sequential degradation by exoglycosidases, gas chromatography, electron impact mass spectrometry and liquid secondary ion-mass spectrometry. Beside G M1, the other fractions were G M3, G D1a and, at a lesser percentage, G M2, all belonging to the same a-ganglio-series. The ceramide part of these parasite gangliosides contained sphingosine associted to unsaturated n24, saturated n24 and n16 fatty acids.
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