Abstract
γδT cells are an unconventional population of T lymphocytes that play an indispensable role in host defense, immune surveillance, and homeostasis of the immune system. They display unique developmental, distributional, and functional patterns and rapidly respond to various insults and contribute to diverse diseases. Although γδT cells make up only a small portion of the total T cell pool, emerging evidence suggest that aberrantly activated γδT cells may play a role in the pathogenesis of psoriasis. Dermal γδT cells are the major IL-17-producing cells in the skin that respond to IL-23 stimulation. Furthermore, γδT cells exhibit memory-cell-like characteristics that mediate repeated episodes of psoriatic inflammation. This review discusses the differentiation, development, distribution, and biological function of γδT cells and the mechanisms by which they contribute to psoriasis. Potential therapeutic approaches targeting these cells in psoriasis have also been detailed.
Highlights
Gamma delta T cells are T cells that have a distinctive T-cell receptor (TCR) on their surface
We hope that this review provides insights into its pathogenesis, especially in disease recurrence, and sheds light on potentially novel therapies targeting gd T cell function
The number of circulating Vg9Vd2 T cells returned to normal levels after successful psoriasis-targeted treatment. These findings demonstrated the redistribution of Vg9Vd2 T cells from the blood to the skin of psoriasis patients [101]
Summary
Reviewed by: Chuan Wu, National Institutes of Health (NIH), United States Eva Reali, University of Milano-Bicocca, Italy. GdT cells are an unconventional population of T lymphocytes that play an indispensable role in host defense, immune surveillance, and homeostasis of the immune system. They display unique developmental, distributional, and functional patterns and rapidly respond to various insults and contribute to diverse diseases. GdT cells make up only a small portion of the total T cell pool, emerging evidence suggest that aberrantly activated gdT cells may play a role in the pathogenesis of psoriasis. Dermal gdT cells are the major IL17-producing cells in the skin that respond to IL-23 stimulation. This review discusses the differentiation, development, distribution, and biological function of gdT cells and the mechanisms by which they contribute to psoriasis. Potential therapeutic approaches targeting these cells in psoriasis have been detailed
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