Abstract
Aim: To evaluate the association between galectin-3 and arterial stiffness among hemodialysis patients. Methods: We enrolled 311 patients (median age: 61years) with a median hemodialysis time of 90 months and a mean galectin-3 concentration of29.78ng/ml. Ninety-six (30.7%) had arterial stiffness diagnosed by the pulse-wave velocity over 10m/s. Results: Galectin-3 was significantly associated with dialysis vintage, calcium, phosphorus and low-density lipoprotein. After adjustment for multiple cardiovascular risk factors, galectin-3 was independently associated with the pulse-wave velocity (partial r=0.130; p=0.035). This effect was still significant after additional adjustment for mean arterial pressure and single-pool Kt/V (partial r=0.139; p=0.014). Conclusion: Galectin-3 is independently associated with arterial stiffness among hemodialysis patients.
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