GALANIN LEVELS IN HYPERTENSIVE PATIENTS WITH OBESITY

Abstract

The aim: To study the level of Galanin concentration in hypertensive patients with obesity, and to identify how the degree of hypertension and the degree of obesity affect the level of Galanin in patients with this comorbid pathology. Materials and methods: The study included 58 patients with hypertension. Grade 1 was diagnosed in 12 (20.69%), grade 2 – 16 (27.59%), grade 3 – 30 (51.72%) examined patients. Of the patients enrolled to study, 32 were women and 26 were men, 32 to 79 years old (mean age – 57,5±10.11 years). Results: The level of Galanin in all groups of hypertensive patients was significantly increased compared to the control group (p < 0.001). The concentration of the latter in the blood serum gradually increases according to the degree of hypertension, while (p<0.01), and the maximum level of Galanin was observed in group of patients with grade 3 hypertension (Me 164.47 pg/mL). The level of Galanin concentration in all subgroups of patients, depending on the presence and degree of obesity, was significantly increased compared to the control group (p < 0.001), the maximum level of Galanin was in the group with hypertension and obesity of 3 degrees (Me = 166.48 pg/mL). Conclusions: In hypertensive patients with obesity, a significant increase in the concentration of Galanin was detected; most pronounced in arterial hypertension grade 3 and obesity grade 3. Galanin is possibly a biomarker of cardiovascular risk in a cohort of patients with abdominal obesity.