Abstract
1. 1. Chick cells maintained in a chemically defined medium developed evidence of severe galactose toxicity while control cells maintained in glucose, mannose or fructose remained normal. 2. 2. In contrast, galactose toxicity was not observed in two normal cell lines of primate origin. 3. 3. Oxidation of galactose to CO 2 occurred in chick cells, but at a much slower rate than in normal primate cells. 4. 4. Galactose had no effect on glucose utilization in chick cells as measured by Co 2 production, but glucose severely inhibited galactose utilization. 5. 5. These observations suggest that galactose toxicity in chick cells is not based on a hyperosmolar state or competition by galactose for glucose transport, but that a biochemical abnormality in galactose metabolism may exist.
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