Abstract
The effect of population density of normal fibroblastic cells on the proliferation of Rous, polyoma and sarcoma 180 cells was studied. The growth of Rous-transformed chick, rat and hamster cells was not inhibited by dense sheets of normal mouse or chick cells. Polyoma and S180 cell growth was inhibited by crowded mouse or rat cells, but not by crowded chick, quail or goose cells. Contact or close apposition of cells was essential for the transmission of growth-inhibitory influences. The transformation of chick cells freshly infected with Rous sarcoma virus was inhibited by dense mouse cells but not chick cells. Both mouse and chick cells exerted a feeder effect on tumour cell growth in monolayer and suspension. The proliferation of mouse and chick cells seeded at different densities was analysed.
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