Galacto-oligosaccharides (GOS) and the Elderly Gut: Implications for Immune Restoration and Health.

Abstract

The increasing prevalence of non-communicable diseases in the aging population has been correlated with a decline in innate and adaptive immune responses; hence, it is imperative to identify approaches to improve immune function, prevent related disorders, and reduce or treat age-associated health complications. Prebiotic supplementation is a promising approach to modulating the gut microbiome and immune system, offering a potential strategy to maintain the integrity of immune function in older individuals. This review summarizes the current research on prebiotic galacto-oligosaccharides (GOS) immunomodulatory mechanisms mediated by bacterial-derived metabolites, including short-chain fatty acids (SCFAs) and secondary bile acids, to maintain immune homeostasis. The potential applications of GOS as immunotherapy for age-related disease prevention in older individuals are also highlighted. This aligns with the global shift towards proactive healthcare and emphasizes the significance of early intervention in directing an individual's health trajectory. Statement of SignificanceThe review provides compelling evidence that GOS, as a dietary intervention, can significantly enhance gut health and immunomodulation in older adults. Based on these findings, the review urges further research to advance our comprehension of GOS and its potential to optimize the health of older individuals.