Gain-of-function mutation Met136Val in SCN8A may not be a common cause of trigeminal neuralgia.

Abstract

BackgroundThe Met136Val mutation in SCN8A was described in a case of trigeminal neuralgia but no frequency among affected individuals was provided.MethodsDirect sequencing of 123 individuals diagnosed with classic trigeminal neuralgia was performed aimed to detect the Met136Val change.ResultsNo cases of classical trigeminal neuralgia studied had the Met136Val mutation in SCN8A.ConclusionMet136Val mutation in SCN8A is not a frequent cause of classical trigeminal neuralgia.