Abstract
We report a one-pot method to directly synthesize magnetic resonance/fluorescence multimodal imaging gadolinium-doped Cu-In-Zn-S quantum dots(GCIZS QDs) in aqueous media by using bio-compatible glutathione (GSH) as capping ligand and stabilizer. The optical features and structure of the GCIZS QDs have been characterized by UV-vis and fluorescence spectroscopy, XRD, TEM, and FT-IR. As a result, The GCIZS QDs possessed a strong fluorescence and r1 value of 4.015 mM-1 s -1 at the Cu/Gd ratio of 1/2. Furthermore, the GCIZS QDs were good water solubility and less cytotoxic up to 250 μg/mL in HUVEC cells. The red emission GCIZS QDs from the MDA-MB-231cells was clearly observed under microscope. It indicated that the GCIZS QDs present great potential as magnetic resonance /fluorescence multimodal imaging contrast agents for biological labels.
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