GABAergic interneurons in cortical network operations

Abstract

Event Abstract Back to Event GABAergic interneurons in cortical network operations Thomas Klausberger1, 2* 1 Center for Brain Research, Med. Uni, Department of Cognitive Neurobiology, Austria 2 Oxford University, MRC Anatomical Neuropharmacology Unit, United Kingdom The distributed temporal activity in neuronal circuits of the prefrontal cortex and hippocampus combines emotional information with episodic and spatial memory to guide decisions on behavioural action. In the hippocampus and medial prefrontal cortex of rodents, single neurons of unknown identity exhibit specific firing patterns during spatial decision-making tasks. The cerebral cortex consists of highly diverse neuronal types with distinct synaptic connectivity, molecular expression profile and contribution to network activity. Cortical neurons can be divided into excitatory pyramidal cells, which use glutamate as a neurotransmitter and give both local and long-range axonal projections, and inhibitory interneurons, which are GABAergic and control the activity and timing of pyramidal cells mainly through local axons. Both types of neuron can be further subdivided on the basis of their distinct axo-dendritic arborisations, subcellular post-synaptic targets, and by their differential expression of signalling molecules, including receptors, ion channels, neuropeptides, transcription factors and Ca2+ binding proteins. In order to explain how neuronal circuits support temporal order leading to higher cognitive functions, it is critical to determine the identity and temporal specificity of neurons. We have recorded identified GABAergic interneurons in the medial prefrontal cortex of anaesthetised rats during network oscillations using the juxtacellular recording and labelling technique and investigated their contribution to the synchronisation of theta oscillations between the hippocampus and medial prefrontal cortex. Furthermore, we recorded the activity of hippocampal and prefrontal interneurons and pyramidal cells with tetrodes in freely-moving rats during the learning and execution of a matching-to-place task on a continuous T maze. Overall, our results indicate that different GABAergic interneurons release GABA at distinct times to different domains of pyramidal cells explaining the need of diverse classes of interneurons. This design of the cerebral cortex is consistent with regulating the input integration of individual pyramidal cells through a dynamic interplay between ion channels and precisely timed synaptic inputs, thereby contributing to the formation of cell assemblies and representations in the hippocampus. Conference: EMBO workshop: Gaba Signalling and Brain Networks , Amsterdam, Netherlands, 30 Jun - 2 Jul, 2010. Presentation Type: Oral Presentation Topic: Talks Citation: Klausberger T (2010). GABAergic interneurons in cortical network operations. Conference Abstract: EMBO workshop: Gaba Signalling and Brain Networks . doi: 10.3389/conf.fnins.2010.15.00043 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Jun 2010; Published Online: 24 Jun 2010. * Correspondence: Thomas Klausberger, Center for Brain Research, Med. Uni, Department of Cognitive Neurobiology, Vienna, Austria, thomas.klausberger@pharm.ox.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Thomas Klausberger Google Thomas Klausberger Google Scholar Thomas Klausberger PubMed Thomas Klausberger Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.