Abstract
In this EBioMedicine manuscript [1], Dr. Guo and colleagues report that the isoflurane-induced loss of consciousness was associated with numerous interesting phenomena, including general decay of GABA input onto each cortical neuron subtype, and diverse glutamate transient in both excitatory and inhibitory interneurons. By using in vivo two-photon imaging with high spatiotemporal resolution and recently developed genetically-encoded neurotransmitter indicators [2], the authors systematically investigate the dynamics of cortical neurotransmitters in a cell type-specific manner during anesthetic-induced unconsciousness which occurred transitorily within tens of seconds.
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