GABA- and glycine-induced Cl − channels in cultured mouse spinal neurons require the same energy to close

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Fluctuation analysis has been used to study the influence of temperature on the conductance and mean open time of Cl − permeable ion channels induced by γ-aminobutyric acid (GABA) and glycine in the membrane of tissue cultured mouse spinal neurons. The conductance of GABA − and glycine-activated channels increased slightly at higher temperatures ( Q 10 ∼ 1.3 ). The mean open times of these channels decreased at higher temperatures ( Q 10 ∼ 3 ). Arrhenius plots for the open times of GABA- and glycine-induced channels were parallel and showed no obvious transition behavior over the temperature range 16–40°C.